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Triglycerides values were not included for analysis since the measurements were confounded by sample hemolysis that interfered with the triglyceride reagent in the assay
NNMT inhibitors display high membrane permeability Compounds spanning ~100-fold IC 50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold[17] to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies
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How can a laboratory select and use a pathway probe with enough confidence that observed biology is not simply an artifact of concentration drift, stability behavior, solvent mismatch, or assay interference
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